Antioxidant and Antiapoptotic Effects of Fraxetin against Lead Induced Toxicity in Human Neuroblastoma Cells

Challa Suresh and Prasanna K Dixit
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Challa Suresh: Department of Biochemistry, National Institute of Nutrition, India
Prasanna K Dixit: Department of Zoology, Berhampur University, India

Organic & Medicinal Chemistry International Journal, 2018, vol. 5, issue 1, 1-6

Abstract: Exposure to lead (Pb), a toxic heavy metal produces a wide range of adverse health effects. Both adults and children can suffer from the effects of Pb-poisoning, but childhood Pb-poisoning is much more frequent. Low-level Pb-exposure can result in reduced IQ, learning disabilities, attention deficit disorders, behavioural problems, stunted growth, impaired hearing, and kidney damage. Oxidative stress is proposed as an intracellular mechanism in Pb-induced toxicity, suggesting the fact that antioxidants might play a very important role in the treatment of Pb-poisoning. The present study was designed to investigate whether fraxetin (FXT), an important coumarin has a beneficial effect on human SH-SY5Y neuroblastoma cells exposed to Pb. In the present study, the cells were exposed to different concentrations (0.01-10 mM) of Pb for 48 hours to determine the concentration (IC50 = 5 mM) at which 50% inhibition in the viability of cells.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:5:y:2018:i:1:p:1-6

DOI: 10.19080/OMCIJ.2018.05.555651

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