Synthesis, Characterization, Thermodynamic and Biological Activity Studies for New Complexes of Some Transition Metals and Zinc With Schiff’s Bases [2,5di (1-Thi-Ophen-2-yl-Ethylidene)-Hydrazine) 1, 3, 4-Thiadiazole]

Hamid Eissa, Naser Shaalan and Shatha Mahde
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Shatha Mahde: Assistant Professor in Physical Organic Chemistry - Chemistry Department, Applied College Sciences, University of Hajah, Yemen

Organic & Medicinal Chemistry International Journal, 2018, vol. 5, issue 2, 55-59

Abstract: New metal complexes of type [M (L)] Cl2, [M (L) Cl2] [(M = Co (II), Ni (II), Cu (II) and Zn (II)] were prepared using the ligand (L) =[2,5di (1-thiophen-2-yl-ethylidene)-hydrazine) 1,3,4-thiadiazole]. The Schiff bases were condensed from [2-acetylthiophene] with [2,5-dihydrazino-1,3,4-thiadiazole] in alcoholic medium. The Schiff bases were tetra dentate ligand that were used for complexion with Co2+, Ni2+, Cu2+ and Zn2+ ions. The prepared complexes were characterized by FTIR, UV-vis as well as magnetic susceptibility, conductivity measurements, atomic absorption, and thermal analysis & Schiff bases characterized by FTIR, UV-vis, 1H-NMR and LC mass spectra and, thermal analysis. The activation thermodynamic parameters, such as ΔE*, ΔH*, ΔS* and ΔG* are calculated from the TGA curve using Coats-Red fern method. From the spectral measurements, structures for the complexes were proposed. Preliminary in vitro tests for antimicrobial activity show that all prepared compounds display good activity to Staphylococcus aureus, Escherishia coli, Pseudononas aeroginosa and Cndida albicans.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:5:y:2018:i:2:p:55-59

DOI: 10.19080/OMCIJ.2018.05.555659

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