Crystal Structure and Disorder in Benzothiophene Derivative

Mohamed Ziaulla
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Mohamed Ziaulla: Department of Chemistry, Impact College of Engineering and Applied Sciences, India

Organic & Medicinal Chemistry International Journal, 2018, vol. 7, issue 5, 125-126

Abstract: Benzothiophenes are important heterocycles either as biological active molecules or as luminescent components used in organic materials [1-3]. One of the most important drugs based on the benzothiophene system is Raloxifene which was approved by the U.S. Food and Drug Administration for the prevention and treatment of osteoporosis in postmenopausal women [4-6]. Raloxifene is a representative of a class of compounds known as selective estrogen receptor modulators (SERMs) that exhibit estrogen agonist-like actions on bone tissues and serum lipids while displaying potent estrogen antagonist properties in the breast and uterus. Recently, 3-oxygenated benzothiophene has been reported to display a substantial (10-fold) increase in estrogen antagonist potency relative to raloxifene [7-11]. We report herein the Crystal structure of 2-Amino-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile (1) and 2-Amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile(2).

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:7:y:2018:i:5:p:125-126

DOI: 10.19080/OMCIJ.2018.07.555721

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