Spectroscopic Evaluation of Novel Tacrine- Coumarin Hybrids as HSA-Interacting Agents

Eva Konkoľová, Monika HudaÄ ová, Slávka Hamuľaková and Mária Kožurková
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Eva Konkoľová: Department of Biochemistry, Faculty of Science, P J Šafárik University, Slovak Republic
Monika HudaÄ ová: Department of Organic Chemistry, Faculty of Science, P J Å afárik University, Slovak Republic
Mária Kožurková: Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 2, 36-42

Abstract: In this work, we investigated the human serum albumin binding behavior of a series of novel derivatives with both tacrine and coumarin pharmacophores. The compounds were investigated using UV-Vis absorption and fluorescence spectroscopy. KB values were found to be in order of 103 M-1. The values of n indicate that only one independent class of binding sites is available for tacrine-coumarin hybrids on HSA. Synchronous fluorescence spectra showed that compounds did not have any noticeably effect on α-helical conformation of HSA. Our data indicated that these tacrine-coumarin molecules exhibit promising potential which would be of considerable use in the development of drugs with enhanced or more selective effects and greater clinical efficacy

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:2:p:36-42

DOI: 10.19080/OMCIJ.2019.08.555733

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