Design and Synthesis of Antifungal Compounds from 1,2,3-Triazoles through the Click Chemistry Approach

Ana Karla Estrada Valdés and Erick Cuevas-Yañez
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Erick Cuevas-Yañez: Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Mexico

Organic & Medicinal Chemistry International Journal, 2019, vol. 8, issue 2, 43-45

Abstract: 1,2,3-triazoles are easily prepared from CuAAC reaction and represent a potential source of antifungal compounds analogous to azole drugs. Accordingly, research groups have synthesized diverse 1,2,3-triazoles with modulated antifungal activity through the substituents in azide or alkyne precursors. A brief review of the state of the art about this topic is presented, focusing the increasing importance of developing new and more selective antifungal compounds.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:8:y:2019:i:2:p:43-45

DOI: 10.19080/OMCIJ.2019.08.555734

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