Influence of Donor and Acceptor Substituents in 1,3-Oxazole Derivatives and their Anti-Cancer Activity

Nataliya V Obernikhina
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Nataliya V Obernikhina: Department of Bioorganic and Biological Chemistry, O.O. Bogomolets National Medical University, Ukraine

Organic & Medicinal Chemistry International Journal, 2019, vol. 9, issue 1, 1-6

Abstract: The heterocyclic compounds with branched conjugated systems including oxazole, thiazole or pirazole moieties have shown themselves as powerful scaffold in drug design, especially, highly active anticancer agents [1]. Consequently, the 1,3-oxazole skeleton could regard as applicable biologically active fragment. This molecular moiety can generate the enough “rigid†structure with the many biopolymers, what is considered as an important condition for increasing of selectivity to potential targets.

Keywords: juniper publishers:Medicinal Chemistry; Biochemistry Journal; Pharmacology Journal; biochemical pharmacology; molecular pharmacology; biochemistry; open access journals; peer reviewed journals; Open Access; Journal of Molecular Biochemistry; International Research Journal of Pure and Applied Chemistry; World Journal of Biological Chemistry; Biochemistry and Analytical Biochemistry; Biochemistry & Physiology: Open Access; Molecular Biology International; Plant Biochemistry & Physiology; International Journal of Molecular Sciences; Journal of Clinical and Medical Genomics; Environmental Analytical Chemistry; Medicinal Chemistry; Juniper publishers reivews (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:adp:jomcij:v:9:y:2019:i:1:p:1-6

DOI: 10.19080/OMCIJ.2019.09.555751

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