Calcified Large Arteries, Osteoporosis & Acute Stroke What is the Relationship

Hesham Hamoud, Abdulaziz A. Mustafa, Husein Mohamad and Gamal El Kheshen
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Abdulaziz A. Mustafa: Rheumatology, Al-Azhar University, Egypt
Husein Mohamad: Neurology & Clinical Pathology Departments, Al-Azhar University, Egypt
Gamal El Kheshen: Clinical pathology Departments, Al-Azhar University, Egypt

Orthopedics and Rheumatology Open Access Journals, 2017, vol. 6, issue 1, 32-38

Abstract: Atherosclerosis and osteoporosis are currently considered unrelated diseases. As age advances, osteoporosis is more frequently found in women than men; atherosclerosis is an illness predominantly affecting men [1]. A parallel relationship has been noted between spinal osteoporosis and aortic calcification due to atherosclerosis [2]. Osteoporosis and stroke share several risk factors, such as age, smoking, low level of physical activity, and hypertension [3]. Thus Low bone mineral density (BMD) and a high risk of stroke may thus be related, but studies on this relationship are sparse. Both bone and atherosclerotic arteries contain osteopontin, matrix gla protein, bone morphogenetic protein collagen I, osteonectin, Osteocalcin, nitric oxide, and matrix vesicles [4]. Atherosclerosis and osteoporosis both involve recruitment and differentiation of monocytic cells that differentiate into macrophage-foam cells in artery and osteoclasts in bone [5]. The artery wall contains cells capable of differentiation into osteoblasts, following the same stages of differentiation as occur in bone-derived osteoblasts, and ultimately producing bone mineral [6].

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Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:adp:joroaj:v:6:y:2017:i:1:p:32-38

DOI: 10.19080/OROAJ.2017.06.555685

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