MODULATION OF COLORECTAL CANCER BY THE PROBIOTIC ORGANISM LACTOBACILLUS REUTERI

Camara A. Blasingame, Leonard H. Billups, Thomas Graham, JaNell Henry, Brianna Carter, David W. Threadgill and A. Deloris Alexander

Professional Agricultural Workers Journal (PAWJ), 2016, vol. 03, issue 2, 16

Abstract: Probiotics are beneficial to gastrointestinal health and have anti-inflammatory properties. An experiment was conducted to determine if L. reuteri could protect mice from azoxymethaneinduced colorectal cancer (AOM-CRC). A/J mice were randomly assigned to controls, pretreatment, or post-treatment groups. The mice in the groups were injected with 10mg/kg body weight of AOM and treated with L. reuteri; given only AOM; given only L. reuteri; or given neither AOM nor L. reuteri. At the end of a 26-week latency period, the mice were euthanized, dissected, and colons examined for tumors. L. reuteri did not protect animals against tumor formation. However, L. reuteri treatment had a significant effect on tumor number when the mice were segregated by gender (p = 0.014). There was no significant effect of regimen on tumor number (p = 0.667) or tumor size (p = 0.197). Ultimately, L. reuteri exhibited probiotic properties as a potential prophylactic treatment for colitis.

Keywords: Health; Economics; and; Policy (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://ageconsearch.umn.edu/record/236898/files/3-2%202016%20PAWJ%20-%201.pdf (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ags:pawjal:236898

DOI: 10.22004/ag.econ.236898

Access Statistics for this article

More articles in Professional Agricultural Workers Journal (PAWJ) from Professional Agricultural Workers Conference
Bibliographic data for series maintained by AgEcon Search ().