Modulatory effects of Micromeria Barbata and 3-acеtyl-11-kеto-boswеllic acid on advanced glycation end products-induced inflammatory cytokine response in THP-1 cells

May Saad (), Ghewa A El-Achkar (), Rana El Hajj (), Abir Abdel Rahman (), Mahmoud I. Khalil () and Nadine Nasreddine ()

Edelweiss Applied Science and Technology, 2025, vol. 9, issue 6, 1815-1835

Abstract: Advanced glycation end products (AGEs) contribute to diabetes complications. They activate inflammation by binding to Receptors for Advanced Glycation End Products (RAGE) on immune cells, triggering cytokine release. Micromeria barbata (MB), a medicinal herb with various biological actions, has not been examined for its anti-inflammatory effects on AGE. Boswellia serrata (BS) research on diabetes and AGE-related conditions is limited. This study examines the anti-inflammatory effects of 3-acetyl-11-keto-boswellic acid (AKBA), BS’s main active component, and MB plant extract on AGE-stimulated THP-1 human monocytic cells. We investigated the impact of AGEs on pro-inflammatory cytokines and the effects of MB plant extract and AKBA on the gene expression of Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α), Interleukin-10 (IL-10), and Interleukin-4 (IL-4) in AGE-stimulated THP-1 cells. THP-1 cells were unaffected by MB, AKBA, and AGE-BSA at various doses. MB and AKBA may reduce AGE-stimulated THP-1 cell inflammation. Treatment with MB and AKBA significantly decreases IL-6 and TNF-α expression. AKBA (0.027 μg/mL) reduces IL-1β gene expression, while MB has no effect. Furthermore, at higher doses, both MB and AKBA significantly increase IL-10 and IL-4 gene expression. This is the first research to reveal MB and AKBA's anti-inflammatory effectiveness, shedding light on natural therapeutic agent development.

Keywords: 3-Acetyl-11-ketoβ boswеllic acid (AKBA); Advanced glycation end products (AGE); Diabetes; Micromeria barbata (MB); Proinflammatory cytokines. (search for similar items in EconPapers)
Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://learning-gate.com/index.php/2576-8484/article/view/8243/2776 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:ajp:edwast:v:9:y:2025:i:6:p:1815-1835:id:8243

Access Statistics for this article

More articles in Edelweiss Applied Science and Technology from Learning Gate
Bibliographic data for series maintained by Melissa Fernandes ().