Protective Effect of Terminalia muelleri Extract on Brain of Streptozotocin-Induced Diabetes in Albino Rats

Sahar B. Ahmed*, Ghada Khiralla, Shimaa Abdalla Harudy and Hesham Elhariry
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Sahar B. Ahmed*: National Organization for Drug Control and Research (NODCAR), Division of Biochemistry, 6-7, AboHazem Street, Pyramids, PO Box 29, Giza, EG
Ghada Khiralla: National Organization for Drug Control and Research (NODCAR), Division of Food Evaluation and Food science, 6-7, AboHazem Street, Pyramids, PO Box 29, Giza, EG
Shimaa Abdalla Harudy: National Organization for Drug Control and Research (NODCAR), Division of Physiology, 6-7, AboHazem Street, Pyramids, PO Box 29, Giza, EG
Hesham Elhariry: Department of Food Science, Faculty of Agriculture, Ain Shams University, PO Box 68-Hadayek Shoubra, Cairo 11241, Egypt

Academic Journal of Life Sciences, 2020, vol. 6, issue 6, 53-60

Abstract: Diabetic neuropathy is one of the complications of diabetes. This study investigated the possibility of reducing neuropathy of STZ-induced diabetic rats by Terminalia muelleri extract (TE) and comparing the effect of the extract with the therapeutic effect of pioglitazone (PG) drug. The experimental animals were divided into non-diabetic (normal control), STZ-induced diabetic (diabetic control), TE-treated non-diabetic (200?mg/kg b.wt) (TE-group) TE-treated diabetic (200?mg/kg b.wt) (TE-STZ-group), and pioglitazone-treated diabetic (1.58 mg /kg b.wt) (PG-STZ-group). All treatments were administered orally by oral gavage once daily throughout the 4?weeks of the treatment period. In this study: malonaldehyde, nitric oxide, reduced glutathione and glutathione disulfide were examined as oxidative stress marker in the brain tissue of the experimental rats. The results indicated high oxidative stress in STZ-diabetic groups and reduced oxidative stress of groups treated with TE. The results of norepinephrine, dopamine, gammaamino- butyric acid, brain-derived neurotrophic factor, and Casps-3 also demonstrated the possibility of using TE to attenuate the effects of neuropathy in experimental rats comparable to PG use. This indicated that the TE is promising alternative to chemical treatment with PG drug. This indicated that TE is promising alternative to chemical treatment with PG drug.

Keywords: Diabetic neuropathy; Terminalia; Brain. (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:arp:ajlsar:2020:p:53-60

DOI: 10.32861/ajls.66.53.60

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