The Effects of Co-Administration of Azadirachta indica and Gongronema latifolium on the Liver of Plasmodium beighei Infected Swiss Albino Mice

Uwemedimo G. Udoh and Aniekan I. Peter*
Additional contact information
Uwemedimo G. Udoh: Department of Anatomy Faculty of Basic Medical Sciences University of, Uyo Nigeria
Aniekan I. Peter*: Department of Anatomy Faculty of Basic Medical Sciences University of, Uyo Nigeria

International Journal of Healthcare and Medical Sciences, 2018, vol. 4, issue 7, 141-146

Abstract: The effects of co-administration of Azadirachta indica and Gongronema latifolium on the liver of Plasmodium beighei infected Swiss albino mice was evaluated. Thirty mice divided into 6 groups of 5 animals each were used for this study. Healthy control group was not infected with. Other group was infected by intraperitoneal injection of P. beighei. Once parasitaemia was confirmed, treatment groups were assigned; Group A received distilled water at 10ml/kg body weight. Group B was not given any extracts. Groups C was given G.latifolium extract at 500mg/kg body weight. Groups D was given A. indica extract at 500 mg/kg body weight. Group E received both extracts at 500 mg/kg each. Group F received Artemether at 1.6mg/kg body weight intraperitoneally. The extracts were administered orally for 5 days. The animals were sacrificed after blood was obtained for serum liver enzymes estimation. The liver were processed for histological study using H and E. Histology of the liver showed sinusoidal congestion and hepatocyte necrosis in the diseased control and steatosis, loss of normal sinusoidal architecture, necrosis of hepatocytes and portal tract inflammation in the A. indica only group. The groups administered G. latifolium, both singly and in combination with A. indica had normal liver histology. The liver enzyme ALT was significantly (p

Keywords: Co-Administration; Azadirachta indica; Gongronema latifolium; Plasmodium beighei; Swiss albino mice. (search for similar items in EconPapers)
Date: 2018
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.arpgweb.com/pdf-files/ijhms4(7)141-146.pdf (application/pdf)
https://www.arpgweb.com/?ic=journal&info=archive&j ... 018&issue=7&volume=4 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:arp:ijohms:2018:p:141-146

Access Statistics for this article

International Journal of Healthcare and Medical Sciences is currently edited by Dr. Bonyah, Ebenezer

More articles in International Journal of Healthcare and Medical Sciences from Academic Research Publishing Group Rahim Yar Khan 64200, Punjab, Pakistan.
Bibliographic data for series maintained by Managing Editor ().