Impact of HIV-Infection on Serum Liver Enzymes: A Comparative Study among Anti-retroviral Therapy (ART) Naïve Patients, ART Follow-Up Patients, and HIV Sero-negative Controls

Agbecha and Ikyernum J. A.
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Agbecha: Department of Chemical Pathology, Federal Medical Centre, Makurdi, Nigeria
Ikyernum J. A.: Department of Medical Microbiology, Virology Unit, Federal Medical Centre, Makurdi, Nigeria

International Journal of Healthcare and Medical Sciences, 2018, vol. 4, issue 12, 196-200

Abstract: Background of study: There is emerging evidence that human immunodeficiency virus (HIV) infection, even in the absence of anti-retroviral therapy (ART) toxicity and other cofactors, may have a direct impact on liver pathogenesis. Aim: Based on this premise, our study determined the impact of HIV infection on liver enzymes as markers of hepatic function. Methods: the case-control study comprised of a total of 60 participants (30 males and 30 females) aged 18-60 years. The study compared aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), cluster of differentiation (CD4+) cells among ART-naïve HIV patients (n=20), follow-up HIV patients who were on highly active ART (n=20) and apparently healthy controls (n=20). Results: a significant (P

Keywords: Human immunodeficiency virus; Aspartate aminotransferase; Alanine aminotransferase; Alkaline phosphatase; Cluster of differentiation 4+ cells. (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:arp:ijohms:2018:p:196-200

DOI: 10.32861/ijhms.412.196.200

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