The Use of Some Selected Antioxidant Supplements in the Management of Fluoride Toxicity on Adult Male Wistar Rats’ Fecundity

Anacletus F. C., Onyegeme-Okerenta B. M. and Iheka C.U.
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Anacletus F. C.: Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria
Onyegeme-Okerenta B. M.: Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria
Iheka C.U.: Department of Biochemistry, Faculty of Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria

Journal of Biotechnology Research, 2016, vol. 2, issue 3, 12-23

Abstract: The use of ameliorative antioxidant potentials of some selected antioxidant supplements in the management of fluoride toxicity on adult male Wistar rats’ fecundity was investigated. Thirty-six adult male albino rats were divided into 6 groups. Group I (positive control) received oral dose of normal feed and water for 4 weeks and 6 weeks, Group II (negative control) sodium fluoride (10mg/kg) body weight (b.w), Group III received sodium fluoride (10mg/kg) + selenium(0.5mg/kg) b.w, Group IV sodium fluoride (10mg/kg) + zinc (14.8mg/kg) b.w, Group V sodium fluoride (10mg/kg) + ginseng (10mg/kg) b.w, Group VI sodium fluoride (10mg/kg) + vitamin E (100mg/kg) b.w. At the end of the 4th and 6th week, hormone assay: (testosterone, prolactin, luteinizing hormone and follicle stimulating hormone, sperm quality analysis: morphology, motility, abnormality, sluggishness, deadness and sperm count) were analysed. Result showed that Group 11 had a significant decrease (p

Keywords: Fluoride toxicity; Antioxidants; Amelioration; Fecundity. (search for similar items in EconPapers)
Date: 2016
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