Local Treatment Strategies in Renal Cell Carcinoma: Current Evidence and Future Directions

Ye Tian and Hongbin Deng
Additional contact information
Ye Tian: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Hongbin Deng: Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

Current Research in Medical Sciences, 2026, vol. 5, issue 2, 61-67

Abstract: The role of local treatment in renal cell carcinoma has been substantially refined in recent years. In localized disease, partial nephrectomy remains the standard treatment because it offers durable oncologic control, complete pathological assessment, and nephron preservation. With the development of cryoablation, radiofrequency ablation, microwave ablation, and stereotactic body radiotherapy, non-surgical local therapies have become important options for selected patients. Percutaneous ablation is best supported in small and technically accessible tumors, whereas stereotactic body radiotherapy provides a noninvasive alternative for patients unsuitable for surgery or invasive procedures. In metastatic renal cell carcinoma, cytoreductive nephrectomy has shifted from a routine upfront strategy to a selective intervention determined by patient selection and treatment sequencing. In oligometastatic and oligoprogressive disease, metastasis-directed local therapy may delay systemic treatment initiation, maintain the benefit of ongoing systemic therapy, and prolong disease control. Overall, local treatment for renal cell carcinoma has moved from isolated technical application toward stage-specific and precision-based integration. Future studies should further clarify indication boundaries, patient selection, treatment timing, long-term renal outcomes, and prospective comparative evidence.

Keywords: renal cell carcinoma; local treatment; partial nephrectomy; stereotactic body radiotherapy; cytoreductive nephrectomy (search for similar items in EconPapers)
Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.paradigmpress.org/crms/article/view/2061/1920 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bdz:curmsc:v:5:y:2026:i:2:p:61-67

DOI: 10.63593/CRMS.2026.03.07

Access Statistics for this article

More articles in Current Research in Medical Sciences from Paradigm Academic Press
Bibliographic data for series maintained by Editorial Office ().