Is Vitamin D Status a Factor Influencing the Onset of Neuropathy in Type 2 Diabetics?

Yosra Hasni, Hamza EL Fekih, Wiem Saafi, Meriem Gueddes, Maissa Thabet, Imen Halloul, Senda Ourdeni, Ghada Saad, Monia Ajina and Amel Maaroufi
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Yosra Hasni: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Hamza EL Fekih: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Wiem Saafi: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Meriem Gueddes: Department of Physiology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Maissa Thabet: Department of Interne Medicine, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Imen Halloul: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Senda Ourdeni: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Ghada Saad: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Monia Ajina: Department of Physiology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia
Amel Maaroufi: Department of Endocrinology and Diabetology, Farhat Hached University Hospital, Sousse; Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia

Journal of Innovations in Medical Research, 2024, vol. 3, issue 4, 55-63

Abstract: Introduction: A growing body of evidence suggests that the role of vitamin D (vit D) is not limited to phosphocalcic homeostasis, but other target organs have also been discovered, justifying a growing interest in this hormone. Although a drop in vit D levels is very common in type 2 diabetes mellitus (T2DM), no study has shown that this is a major factor in the onset of diabetic neuropathy. The aim of this study was to determine the prevalence of vit D deficiency in patients with T2DM, to identify factors influencing vit D status and to study the association between vit D deficiency and the development of neuropathy in patients with type T2DM. Methods: A cross-sectional study was conducted at the Farhat Hached University Hospital Centre (CHU) in Sousse, among type 2 diabetic patients aged between 25 and 70 years. All patients presenting a physiological or pathological situation likely to lead to hypovitaminosis D were excluded. Results: A total of 155 patients were included. There were 62 men (40%) and 93 women (60%), giving a sex ratio of 0.66. Nearly 2/3 (64%) were over 50 years of age, with a mean age of 53.4±10.8 years. Diabetic peripheral neuropathy was diagnosed in 40% (62 patients) of cases with a mean DN4 score of 2.8 ± 2.67. The most common vegetative neuropathy was cardiovascular autonomic neuropathy (29.23%), followed by gastrointestinal digestive neuropathy (26.15%). Only one patient with neuropathy had normal vitamin status and almost all (60 patients) had vit D levels below 20 ng/ml. The mean vit D level was significantly lower in diabetics with neuropathy than in those without this complication (p≤ 10-3). There was a statistically significant negative correlation between mean vit D level and DN4 score (p=10-3). The univariate study showed that a vit D level

Keywords: type 2 diabetes mellitus; diabetic neuropathy; microangiopathy; complications of diabetes; vitamin D (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:bdz:joimer:v:3:y:2024:i:4:p:55-63

DOI: 10.56397/JIMR/2024.12.07

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