The Potential Antifungal and Antibacterial of 5- Chloro-1- Methyl- 4- Nitroimidazole

I.O. Eriamiatoe, B.J. Owolabi, H.C. Ndibe, Mzozoyana and T. Eriamiatoe
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I.O. Eriamiatoe: Department of Chemistry, University of Benin, Benin City, Edo State, Nigeria
B.J. Owolabi: Chemistry Department, Federal University of Technology, Akure, Ondo State, Nigeria
H.C. Ndibe: Department of Chemistry, University of Benin, Benin City, Edo State, Nigeria
Mzozoyana: Chemistry Department, Federal University of Technology, Akure, Ondo State, Nigeria
T. Eriamiatoe: Department of Chemistry, University of Benin, Benin City, Edo State, Nigeria

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 7, 366-372

Abstract: Imidazole is a nitrogen-containing heterocyclic ring that possesses biological and pharmaceutical importance. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid, while the nitroimidazole and its derivatives possess an extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to evaluate the in vitro antifungal and antibacterial activities of 5-chloro-1-methyl-4-nitroimidazole. The synthesis of this compound was carried out via a three-step reaction such as aminolysis, chlorination and nitration. From the FT-IR, 1H NMR, and 13C NMR spectra of the obtained compound, the absorption bands, signals, and coupling constant conform to the proposed compound. Furthermore, when tested for its in-vitro antifungal and antibacterial activities, the derivative showed excellent antifungal activity against a clinical strain of Candida albicans and Aspergillus niger at a minimum bactericidal concentration of 2.5 mg/mL, while the bacterial isolate of Pseudomonas aeruginosa and Klebsiella. pneumonie was at 4.0 mg/mL.

Date: 2024
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