Evaluation of CD4+ T Lymphocytes and Renal Function Status of Naïve Human Immunodeficiency Virus-Infected Premenopausal Females

Romanus Ogai Ogalagu
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Romanus Ogai Ogalagu: Department of Biochemistry, Faculty of Natural and Applied Sciences, Tansian University, Umunya, Anambra state, Nigeria.

International Journal of Research and Scientific Innovation, 2025, vol. 12, issue 2, 1157-1163

Abstract: There is no known cure for HIV infection. However, effective preventive interventions are available that will enhance the sustainability and overall wellbeing of the patients as well as prevent vertical transmission from mother to child. This study was aimed at evaluating the renal function status of Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome – infected pre-menopausal females relative to the matched control group. The subjects used in the study were 80 HIV- positive females aged between twenty to thirty five years at the President’s Emergency Plan for AIDS Relief (PEPFAR), HIV clinic, University of Nigeria Teaching Hospital (UNTH), Enugu. Samples from 80 apparently healthy non-HIV positive age-matched female volunteers served as the control group. The blood samples were collected using standard methods. HIV re-screening and confirmation were carried out using WHO HIV test algorithm. Automated method using Flow cytometry was used for the enumeration of CD4+ T Lymphocytes while renal function parameters of the test subjects and the control group were carried out using standard methods. There was a significant increase P

Date: 2025
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