The Effects of the Extracts of Ginger and Aloe Vera on Wistar Rats Model of Type 2 Diabetes Induced With Dexamethasone and High Fat Diet

B. M. Aleme, A.a Uwakwe and B. A. Amadi
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B. M. Aleme: Department of Biochemistry University of Port Harcourt. Rivers State Nigeria
A.a Uwakwe: Department of Biochemistry University of Port Harcourt. Rivers State Nigeria
B. A. Amadi: Department of Biochemistry University of Port Harcourt. Rivers State Nigeria

International Journal of Research and Scientific Innovation, 2020, vol. 7, issue 2, 208-214

Abstract: Africa and Nigeria to be precise is characterized by a rich diversity of ethno-medicinal plants as well as a rich traditional medicine system. An ethno-botanical survey was conducted to collect information about medicinal plants used for the treatment of diabetes especially the type 2 diabetes, ginger and aloe vera were part of the commonly used plant parts in Nigeria. This study assessed insulin resistance in normal and diabetic animal subjects using homeostatic model (HOMAIR). The research compared the effectiveness of natural plants extract (ginger and aloe vera) source with and without two anti-insulin resistant drugs (Glimepiride and Metformin) and one anti-insulin resistant herb (Cinnamon) after inducement of insulin resistance by dexamethasone and high fat diet (25% lard, 7% egg, and 15% sucrose). The study evaluate dyslipidaemia and hyperinsulinaemia in sampled subjects Eighty four wistar albino rats were used in this study, being divided into fourteen groups of six rats each and fed with high fat diet, inducted with dexamethasone, and treated with Glimepiride, Metformin, Cinnamon, Ginger, and Aloe vera in various doses with the exception of the normal and negative controls. Each sample of blood serum and plasma was analyzed using Randox kits to test for various biochemical parameters. Compared with the normal control, the mean values of the parameters were significantly different (p

Date: 2020
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