Hypoglycemic Property of Different Fractions of Crude Ethanol Extract of Azadirachta indica Leaves in Streptozotocin-induced Diabetic Rats

Obiajulu Christian Ezeigwe, Chukwuemeka Obumneme Okpala, Chidimma Stella-Maris Okeke, Perpetua Chiamaka Amuzie, Blessing Adaobi Okeke, Chiemeka Princess-Dolorosa Ikechukwu, Ejike Celestine Orji and Naomi Ngozi Nnadi
Additional contact information
Obiajulu Christian Ezeigwe: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Chukwuemeka Obumneme Okpala: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Chidimma Stella-Maris Okeke: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Perpetua Chiamaka Amuzie: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Blessing Adaobi Okeke: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Chiemeka Princess-Dolorosa Ikechukwu: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Ejike Celestine Orji: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria
Naomi Ngozi Nnadi: Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria

International Journal of Research and Scientific Innovation, 2020, vol. 7, issue 6, 190-194

Abstract: Background: Azadirachta indica (AI) is used in the traditional management of diabetes in Nigeria. This study investigated the hypoglycemic potential of Azadirachta indica leaf fractions (AILF) in streptozotocin-induced diabetic male rats. Methods: Ethanol crude extract of AI leaf was fractionated with solvents of increasing order of polarity (n-hexane, chloroform, ethyl-acetate, and n-butanol). Phytochemical analysis was done using standard methods. Diabetes mellitus was induced in the rats intraperitoneally with 50mg/kg bodyweight of streptozotocin. Treatment with the AILF was done for a period of twenty-eight days to ascertain which of the AILF possess better hypoglycemic property. Fasting blood glucose levels were checked at one week intervals using One Touch Glucometer and Test Strips. Results: Bioactive compounds detected in moderate and trace amounts in the AILF include alkaloids, cyanogenic glycosides, flavonoids, phenols, saponin and tannins. Induction of diabetes caused a significant (p

Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.rsisinternational.org/journals/ijrsi/d ... -issue-6/190-194.pdf (application/pdf)
https://www.rsisinternational.org/virtual-library/ ... duced-diabetic-rats/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bjc:journl:v:7:y:2020:i:6:p:190-194

Access Statistics for this article

International Journal of Research and Scientific Innovation is currently edited by Dr. Renu Malsaria

More articles in International Journal of Research and Scientific Innovation from International Journal of Research and Scientific Innovation (IJRSI)
Bibliographic data for series maintained by Dr. Renu Malsaria ().