Statin Use Will Cure Disease? A Review of Statin Safety and Efficacy

Fathimath Shahban, Dr. Linu Mohan P, Lubana Kv and Asha G
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Fathimath Shahban: Alshifa College of Pharmacy, Kerala, India
Dr. Linu Mohan P: Alshifa College of Pharmacy, Kerala, India
Lubana Kv: Alshifa College of Pharmacy, Kerala, India
Asha G: Alshifa College of Pharmacy, Kerala, India

International Journal of Research and Scientific Innovation, 2020, vol. 7, issue 7, 119-122

Abstract: Statins [HMG COA reductase inhibitors] are very much effective in reducing the low density lipoproteins [LDL] cholesterol in patients with risk of coronary artery diseases and cerebrovascular events. Statins competitively inhibit the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase which acts as the catalyst in the cholesterol synthesis pathway (mevalonate pathway). Statins reduce the low density lipoproteins [LDL] cholesterol depends on the strength /dose. A high dose of statin will reduce >50% of LDL cholesterol. Also reduces the atherosclerotic events, leading cause of cardiovascular and cerebro vascular diseases. Apart from the benefits, statin use may show some side effects like myopathy, Rhabdomyolysis, increased transaminase level, new onset diabetes. This article discusses the benefits and safety of statins.

Date: 2020
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