Antiurolithiatic Activity of Calliandra Haematocephala Leaf Extract in Ethylene-Glycol Induced Wistar Rat Model

Opeyemi O. Fayehun, Morayo B Adediran, Labunmi Lajide, Zaccheus S Ololade and Dare J Aseperi
Additional contact information
Opeyemi O. Fayehun: Department of Integrated science, Adeyemi Federal University of Education, Ondo State, Nigeria
Morayo B Adediran: Department of Integrated science, Adeyemi Federal University of Education, Ondo State, Nigeria
Labunmi Lajide: Department of Chemistry, University of Medical sciences, Ondo State, Nigeria
Zaccheus S Ololade: Department of Chemistry, Adeyemi Federal University of Education, Ondo State, Nigeria
Dare J Aseperi: Department of Chemistry, Adeyemi Federal University of Education, Ondo State, Nigeria

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 4, 723-740

Abstract: Traditionally, Calliandra haematocephala is used for the treatment of kidney stones. Urolithiasis, also known as the formation of urinary stones, is a health problem that affects nearly all populations worldwide, causing severe acute back pain and occasionally leading to more severe complications, such as pyelonephritis or acute renal failure. The antiurolithiatic activity of this plant has not been documented, hence this study sought to incorporate chemical analysis such as HPLC and GC-MS and biological evaluation to ascertain the effect of this plant in ethylene-glycol-induced Wistar rats. The presence of secondary metabolites was detected using standard methods. Agilent 1100 HPLC with a variable wavelength UV detector and Shimadzu GC-MS-QP2010 Plus were used for the HPLC and GC-MS analysis respectively. Antimicrobial analysis was done using the diffusion method, and a Membrane Perturbation assay was performed to evaluate the ability of the plant to stabilize the membrane. Biochemical and histological analysis was performed using commercial kits.

Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.rsisinternational.org/journals/ijrias/ ... -issue-4/723-740.pdf (application/pdf)
https://rsisinternational.org/journals/ijrias/arti ... ed-wistar-rat-model/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bjf:journl:v:10:y:2025:i:4:p:723-740

Access Statistics for this article

International Journal of Research and Innovation in Applied Science is currently edited by Dr. Renu Malsaria

More articles in International Journal of Research and Innovation in Applied Science from International Journal of Research and Innovation in Applied Science (IJRIAS)
Bibliographic data for series maintained by Dr. Renu Malsaria ().