Potential of Muntingia Calabura L. Leaf Extract Cream on the Late Remodeling Phase of Wound Healing in Diabetic Rats (Rattus Norvegicus)

Muhammad Nur Salim, Siti Aisyah, Dian Masyitha, Rumi Sahara Zamzami and Betrianis
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Muhammad Nur Salim: Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia
Siti Aisyah: Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia
Dian Masyitha: Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia
Rumi Sahara Zamzami: Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia
Betrianis: Faculty of Veterinary Medicine, Syiah Kuala University, Banda Aceh, Indonesia

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 6, 1885-1891

Abstract: Wound healing is a complex biological mechanism of the body that repairs damaged tissue by involving various cellular activities. This study aimed to determine the effectiveness of Muntingia calabura L. leaf extract cream to accelerate incision wound healing on day 21 in white rats (Rattus norvegicus) with diabetes mellitus. This experiment used 12 male white rats weighing 150-200 g and 2-3 months old, induced by a single dose of streptozotocin. The incision was made on the paravertebral area along 2 cm and a depth of 2 mm. Wound therapy was given twice a day for 21 days, P1 was given cream base and distilled water , P2 was given 0.1% silver sulfadiazine cream and metformin 4, 5 mg/k g weight, P3 and P4 were given 5% and 15% Muntingia calabura L. leaf extract cream with oral extract 450 mg/k g body weight. ANOVA test results showed a significant effect (P

Date: 2025
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