Estimating Risks of Progressing to Aids When Covariates are Measured with Error

J. Raboud, N. Reid, R. A. Coates and V. T. Farewell

Journal of the Royal Statistical Society Series A, 1993, vol. 156, issue 3, 393-406

Abstract: For some time, there has been interest in quantifying the risks of progressing to Aids from infection with the human immunodeficiency virus (HIV) associated with changes in the immunological markers. Until recently, little attention has been paid to the considerable variability of these markers and the corresponding effect on estimates of relative risk. We estimate the risks of progression to Aids associated with immunological markers among a group of homosexual men infected with HIV who have been followed at quarterly intervals for 5 years. Errors in measurement in the markers are shown to bias these estimates. Smoothing techniques are compared for their effectiveness in reducing the amount of variation in the markers and the subsequent bias in the coefficients. A simulation study compares the effectiveness of various methods of smoothing in reducing the bias of the estimated coefficient.

Date: 1993
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://doi.org/10.2307/2983065

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bla:jorssa:v:156:y:1993:i:3:p:393-406

Ordering information: This journal article can be ordered from
http://ordering.onli ... 1111/(ISSN)1467-985X

Access Statistics for this article

Journal of the Royal Statistical Society Series A is currently edited by A. Chevalier and L. Sharples

More articles in Journal of the Royal Statistical Society Series A from Royal Statistical Society Contact information at EDIRC.
Bibliographic data for series maintained by Wiley Content Delivery ().