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A Bayesian inference for the penalized spline joint models of longitudinal and time-to-event data: A prior sensitivity analysis

Thi Thu Pham Huong (), Pham Hoa () and Nur Darfiana ()
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Thi Thu Pham Huong: Mathematical Department, An Giang University, Vietnam National University, Ho Chi Minh City, Vietnam
Pham Hoa: Mathematical Department, An Giang University, Vietnam National University, Ho Chi Minh City, Vietnam
Nur Darfiana: CSEM, Flinders University, Flinders at Tonley, GPO BOX 2100, Adelaide5001, South Australia, Australia

Monte Carlo Methods and Applications, 2020, vol. 26, issue 1, 49-68

Abstract: Bayesian approaches have been used in the literature to estimate the parameters for joint models of longitudinal and time-to-event data. The main aim of this paper is to analyze the impact of prior distributions on estimating parameters in a proposed fully Bayesian analysis setting for the penalized spline joint models. To achieve this aim, the joint posterior distribution of parameters in survival and longitudinal submodels is presented. The Markov chain Monte Carlo (MCMC) algorithm is then proposed, which consists of the Gibbs sampler (GS) and Metropolis Hastings (MH) algorithms to sample for the target conditional posterior distributions. The prior sensitivity analysis for the baseline hazard rate and association parameters is performed through simulation studies and a case study.

Keywords: Survival data; longitudinal data; joint models; Bayesian approach; random effects (search for similar items in EconPapers)
Date: 2020
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DOI: 10.1515/mcma-2020-2058

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