Mesobiliverdin IXα-enriched microalgae feed improves gut health in weaned piglets under LPS challenge

Tz-Shian Liao, Pei-En Chang, Yi-Ting Chen, Ching-Yi Chen, Cheng-Wei Tom Chang, Jon YutakaTakemoto and Yuan-Yu Lin
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Tz-Shian Liao: Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan
Pei-En Chang: Institute of Biotechnology, National Taiwan University, Taipei City, Taiwan
Yi-Ting Chen: Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan
Ching-Yi Chen: Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan
Cheng-Wei Tom Chang: Department of Chemistry and Biochemistry, Utah State University, Logan, Utah, USA
Jon YutakaTakemoto: Department of Biology, Utah State University, Logan, Utah, USA
Yuan-Yu Lin: Department of Animal Science and Technology, National Taiwan University, Taipei City, Taiwan

Czech Journal of Animal Science, 2025, vol. 70, issue 4, 139-146

Abstract: This study aimed to evaluate the effect of mesobiliverdin IXα-enriched microalgae (MBV-SP) on growth, diarrhoea prevalence, intestinal morphology, antioxidant capacity, and inflammatory cytokines in lipopolysaccharide (LPS)-induced enteritis in weaned piglets. Seventy-two 28-day-old piglets were randomly divided into four groups: control (NC), LPS, tylosin, and MBV-SP, with saline/LPS (100 µg/kg) administered intraperitoneally on day 14. Results showed reduced mortality and diarrhoea rates in the tylosin + LPS and MBV-SP + LPS groups compared to the LPS group. Histological analysis revealed improved villus morphology and decreased crypt depth in the MBV-SP group. Catalase activity was notably higher in the MBV-SP group. Both tylosin and MBV-SP supplementation reduced pro-inflammatory cytokines, with MBV-SP exhibiting a more pronounced effect. In conclusion, MBV-SP mitigated diarrhoea, improved antioxidant capacity, and modulated inflammatory cytokines in weaned piglets with LPS-induced enteritis, highlighting its potential as a dietary supplement for the gut health in piglets.

Keywords: lipopolysaccharide; mesobiliverdin IXα; microalgae; weaned piglets (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlcjs:v:70:y:2025:i:4:id:159-2024-cjas

DOI: 10.17221/159/2024-CJAS

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