An influence of cisplatin on the cell culture of Nicotiana tabacum BY-2

P. Babula, V. Šupálková, V. Adam, L. Havel, M. Beklová, Z. Sladký and R. Kizek
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P. Babula: Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
V. Šupálková: Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry in Brno, Czech Republic
V. Adam: Department of Veterinary Ecology and Environmental Protection, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
L. Havel: Department of Plant Biology, Mendel University of Agriculture and Forestry in Brno, Czech Republic
M. Beklová: Department of Plant Biology, Mendel University of Agriculture and Forestry in Brno, Czech Republic
Z. Sladký: Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
R. Kizek: Department of Chemistry and Biochemistry, Mendel University of Agriculture and Forestry in Brno, Czech Republic

Plant, Soil and Environment, 2007, vol. 53, issue 8, 350-354

Abstract: The mechanism of cisplatin effect has been well examined in in vitro models of malignant cell lines, but has never been studied on plant cell lines. When plant cell suspension culture of Nicotiana tabacum BY-2 was treated with cisplatin a decrease of viability with its increasing concentration was observed as well as the mitotic index. The structure of nuclei has also been changed in dependence on cisplatin concentration.

Keywords: cisplatin; Nicotiana tabacum BY-2; cell viability; nucleus; DNA (search for similar items in EconPapers)
Date: 2007
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlpse:v:53:y:2007:i:8:id:2213-pse

DOI: 10.17221/2213-PSE

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