Clinical and immunohistochemical findings of splenic mast cell tumour in a cat: A case report

S Lee, Kang Ms, Y Jeong, Y Kim, Kwak Hh, Choi Ew, S Choi, I Park, Chung Jy, Choi Jh and Ahn Jo
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S Lee: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Kang Ms: Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Y Jeong: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Y Kim: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Kwak Hh: Department of Veterinary Surgery, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Choi Ew: Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
S Choi: Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea Seokwoo Lee and Min Soo Kang contributed equally to this work
I Park: Department of Veterinary Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea Seokwoo Lee and Min Soo Kang contributed equally to this work
Chung Jy: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Choi Jh: Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea
Ahn Jo: Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea

Veterinární medicína, 2021, vol. 66, issue 11, 498-502

Abstract: A 6-year-old, spayed, female, domestic shorthair cat presented with a 4-month history of chronic intermittent vomiting and anorexia. The haematologic results indicated moderate anaemia and a circulating mast cell population. The abdominal radiography revealed a markedly enlarged spleen. The cytological analysis of the spleen showed a uniform population of mast cells, and a diagnosis of systemic mastocytosis (splenic mast cell tumour with mastocytaemia) was made. This diagnosis was subsequently confirmed by the histopathological examination of the spleen. The immunohistochemistry for KIT showed KIT pattern II (focal cytoplasmic expression). A splenectomy and chemotherapy with vinblastine and prednisolone resulted in remission of the anaemia and other clinical signs. This case report highlights the importance of cytological evaluations of peripheral blood smears and/or aspirates of enlarged spleens for diagnosing splenic mast cell tumours and for quickly initiating the appropriate treatment.

Keywords: KIT; mastocytaemia; prednisolone; spleen; splenectomy; vinblastine (search for similar items in EconPapers)
Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:66:y:2021:i:11:id:11-2021-vetmed

DOI: 10.17221/11/2021-VETMED

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