Uterine angiomyofibroblastoma in a domestic cat: A need of precise diagnosis for proper perioperative management

Kim Tu, Park Js, Yim Jh, Kim Wj, Hong Sb, Jung Yr, Choi Sk, Baek Sm and Park Jk
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Kim Tu: Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Park Js: Gumi Top Animal Medical Center, Gumi, Republic of Korea
Yim Jh: Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Kim Wj: Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Hong Sb: Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Jung Yr: Daegu Health College, Department of Companion Animal Health Management, Daegu, Republic of Korea
Choi Sk: Core Protein Resources Center, Daegu-Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea
Baek Sm: Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Park Jk: Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea

Veterinární medicína, 2025, vol. 70, issue 5, 177-183

Abstract: Angiomyofibroblastoma (AMFB) is rarely reported in humans as well as domestic animals, especially in the female genital tract. This painless tumour is characterised by the proliferation of spindle or ovoid tumour cells with myofibroblastic differentiation, which often cluster around thin-walled blood vessels. This report presents a case of feline AMFB for the first time. Preoperative abdominal radiography demonstrated an enlarged uterus with the dorsolateral displacement of the ovaries, and transabdominal ultrasonography showed an enlarged uterus with diffuse hypoechoic areas. The resected uterus showed a firm texture with a grey to brownish colour. A microscopic examination revealed proliferation of well-differentiated neoplastic spindle cells on a background of abundant fibrous stroma containing numerous blood vessels. Myxoid degeneration and vascular extravasation were not observed. The neoplastic cells were diffusely immunopositive for α-SMA and vimentin and focally positive for desmin (in the perivascular areas). AMFB is rare in veterinary medicine and the feline uterine AMFB observed in the present case had not been previously reported. Although previously reported as a safe, benign tumour, a surgical procedure of a large AMFB in small animals without proper diagnosis may become life-threatening.

Keywords: α; -SMA; desmin; feline; hemangiopericytoma; uterus (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:caa:jnlvet:v:70:y:2025:i:5:id:88-2024-vetmed

DOI: 10.17221/88/2024-VETMED

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