Costo efectividad del trasplante alogénico con progenitores hematopoyéticos no emparentados comparado con quimioterapia en el tratamiento de la leucemia mieloide aguda de riesgo alto en población pediátrica

Mario García-Molina, Liliana Chicaíza-Becerra, Hoover Quitian-Reyes, Adriana Linares-Ballesteros and Oscar Ramírez Wuttemberger

Econógrafos, Escuela de Economía from Universidad Nacional de Colombia, FCE, CID

Abstract: Objetive: To assess the cost effectiveness of unrelated stem cell transplantation versus consolidation chemotherapy in pediatric population with high-risk acute myeloid leukemia (AML).

Methods: A decision tree model was built with life years gained as outcome, from the perspective of the health system, including all direct costs. Pharmaceutical prices were obtained from the official System of Information of Medicaments SISMED (2008), and the value of procedures was calculated from the 2001 ISS tariff manual adding 30%. All monetary amounts are expressed in Colombian pesos of 2010. No discount rate wasapplied as costs are incurred during the first year. The cost-effectiveness threshold used was three times the 2010 per capita GDP per life year gained.Deterministic and probabilistic sensitivity analyses were performed over the variables with the higher effecton the incremental cost-effectiveness ratio (ICER).

Results: The ICER of transplantation was $9.226.421, which is lower than the per capitaGDP of 2010, $12.047.418. Results are robust to changes in the model data. Probabilisticsensitivity analysis with ten thousand simulations showed that unrelated transplant has a70% probability of being cost effective.

Conclusions: In the Colombian health system, unrelated stem cell transplantation is a cost-effective strategy for the treatment of high risk AML in pediatric patients.

Keywords: Cost-benefit analysis; Cost effectiveness; Health economics; Acute myeloid leukemia; unrelated hematopoietic stem cell transplantation; chemotherapy (search for similar items in EconPapers)
JEL-codes: D61 I10 I12 I19 (search for similar items in EconPapers)
Pages: 33
Date: 2012-07
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Persistent link: https://EconPapers.repec.org/RePEc:col:000176:022964

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