Comparative Efficacy of Tranexamic Acid Versus Vitamin C in the Treatment of Melasma with Microneedling

Denisse Díaz Aguilera, Kendry Morales Pérez, Linet Laura Díaz Aguilera and Sara Mosquera Ferras

SAP Primary Care, 2026

Abstract: Melasma is a common pigmentary dermatosis in women that affects quality of life and is resistant to conventional treatments. This study analyzed the efficacy of tranexamic acid and vitamin C (ascorbic acid), associated with microneedling, in a sample of six women drawn from a population of 10 candidates. Variables such as age, lesion evolution time, number of sessions, and clinical differences between both treatments were evaluated. The results indicated a significant reduction in the melanin index in both groups, with moderate statistical superiority in the tranexamic acid group. Mechanisms of action, limitations, and clinical recommendations are discussed.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:cwf:pcarti:pc2026123

DOI: 10.62486/pc2026123

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