Fluoroquinolones and tendon rupture in a spontaneous reporting database: a disproportionality analysis

Claudia Diaz-de la Rosa, Claudia031299@gmail.com, Luis Enrique Jiménez-Franco, Roxana Toledo del Llano, Emilio Vega-Cardulis and Ofelia Cardulis-Cárdenas

SAP Podiatry, 2024

Abstract: Introduction: Fluoroquinolones are associated with tendon injury, but the disproportionality of tendon rupture relative to other antibiotics in spontaneous reporting remains incompletely quantified. Methods: A case/non-case analysis of the FDA Adverse Event Reporting System was performed through the openFDA interface using reports received from 2004 to 2024. Reporting odds ratios and proportional reporting ratios with 95% confidence intervals were computed for tendon rupture and tendinitis, comparing fluoroquinolones with other antibiotics, with subgroup analyses by sex, age and seriousness. Results: Fluoroquinolones were recorded in 1,916 tendon rupture and 3,238 tendinitis reports, versus 300 and 518 for other antibiotics. The reporting odds ratio was 22.49 (95% CI 19.91-25.40) for tendon rupture and 22.18 (95% CI 20.22-24.34) for tendinitis. The signal was highest in adults aged 65 years or older (26.10) and similar between the sexes; the median age of cases was 63 years and 94.4% were serious. Conclusions: Tendon rupture and tendinitis are disproportionately reported with fluoroquinolones compared with other antibiotics, particularly in older adults, reinforcing the restriction of these agents in patients at risk.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:cwf:podart:pod2024110

DOI: 10.62486/pod2024110

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