Oxigenoterapia hiperbárica para las úlceras del pie diabético: una revisión sistemática

Juan Carlos Pérez González, Diana Paola Silva González and Mayra Sherlyn Zúñiga Martínez

SAP Podiatry, 2025

Abstract: Introduction: Diabetic foot ulcers precede most diabetes-related lower-limb amputations, and adjunctive hyperbaric oxygen therapy is widely used to accelerate healing although the evidence for its effect on amputation remains conflicting. Methods: We searched Scopus, PubMed, OpenAlex and Crossref for randomized trials and observational studies published between 2016 and 2025 that compared systemic hyperbaric oxygen therapy with standard wound care in adults with diabetic foot ulcers and reported ulcer healing or amputation. Risk of bias was assessed with the RoB 2 tool and the Newcastle-Ottawa Scale, and results were synthesized narratively by outcome dimension. Results: From 490 records, 17 studies were included, comprising 7 randomized trials and 10 observational studies. Small randomized trials reported higher healing rates with hyperbaric oxygen, but the two largest sham-controlled trials found no significant benefit for healing or amputation. Healing rates in observational cohorts ranged from 36% to 75%, and major amputation rates ranged from 6% to 16%. Conclusions: Hyperbaric oxygen therapy may improve ulcer healing in selected patients, but adequately controlled trials do not demonstrate a consistent reduction in major amputation, and the certainty of the evidence remains low.

Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:cwf:podart:pod2025170

DOI: 10.62486/pod2025170

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