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Towards a risk classification for tumor lysis syndrome in solid neoplasms

José Grabiel Correa Rodríguez, Leonardo Manuel Castell Martínez and Nadia del Rosario Blanco Fiqueredo

SAP Health and Policy, 2026

Abstract: Introduction: Tumor lysis syndrome in solid tumors is a rare complication associated with high mortality. Its exclusion from clinical practice guideline risk classifications, as well as its underestimation, exacerbates this gap. Objective: To propose hypotheses for a risk classification model for tumor lysis syndrome in solid tumors. Development: Risk classification for tumor lysis syndrome in solid tumors should include three categories: high, intermediate, and low. In addition, there are factors that can increase the risk, such as metastatic burden, elevated lactate dehydrogenase levels, pre-existing renal and/or hepatic impairment, and disseminated intravascular coagulation. Conclusions: Although traditionally considered low-risk, tumor lysis syndrome in solid tumors should be addressed with classification models that allow for its appropriate stratification in daily clinical practice.

Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:cwf:shpart:shp2026326

DOI: 10.62486/shp2026326

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