Transient Global Amnesia in Adult and Elderly Z-Drug Users: A Systematic Review

Laíse Rohde Sorato and Marcelo Adrián Estrin
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Laíse Rohde Sorato: Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud. Carrera de Medicina, Argentina
Marcelo Adrián Estrin: Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud. Carrera de Medicina, Argentina

International Journal of Neurology, 2023, vol. 57, 74

Abstract: Introduction: Sleep is crucial for an individual's physical and mental well-being, and problems related to sleep disorders are associated with significant morbidity and mortality. Z-drugs were developed with superior pharmacokinetics to benzodiazepines and are now recognized and authorized for the treatment of insomnia. Despite their superior pharmacokinetics, Z-drugs are associated with a concerning adverse effect: transient global amnesia. Materials and methods: This systematic review was conducted using articles published between 2006 and 2021. In addition, the risk factors associated with its onset were investigated. Results: A total of 783 patients were included. The study with the most patients had 516 and the one with the fewest had 1, with a mean of 78.3. Of the total number of patients, 104 (13.28%) presented with transient global amnesia. The study that reported the most patients had 79 and the one with the fewest had 1, with a mean of 10.4. Conclusion: Before prescribing a Z-hypnotic, the physician should consider whether the patient lives alone, takes other psychotropic drugs, takes many medications concomitantly, or is malnourished, because, as this review concludes, all of these are risk factors for transient global amnesia.

Keywords: Zolpidem; Amnesia; Transient Global; Transient Global/epidemiology; zaleplon; zopiclone (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:cwh:ijneur:v:57:y:2023:id:74

DOI: 10.62486/ijn202374

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