Late efects of retinoblastoma treatments

Raphaella Alves Leal

SCT Proceedings in Interdisciplinary Insights and Innovations, 2025, vol. 3, 10.56294/piii2025560

Abstract: Retinoblastoma is a most common primary intraocular malignant intraocular tumor in pediatric patients younger than 4 years. If diagnosed and treated quickly and effectively, it has a high chance of cure. Enucleation and exenteration are standard treatment methods with better prognosis of cure, however, nowadays, it should be noted that the above mentioned techniques are mainly used in more advanced cases of the disease such as in massive tumors, with invasion to the optic nerve or choroid and in failures of previous therapies. However, in the last 30 years, new treatments to save the eyeball have been employed with good results and are increasingly used. The study aims to describe and compare the different therapeutic approaches currently available, with a combination of better prognosis and fewer side effects of treatment for different stages, highlighting the individuality of the patient and assessing the characteristics of the tumor, location, histology, optic nerve invasion and presence of metastases. A descriptive study in which data selection is used for the research by searching in Internet pages such as: PubMed, Google Scholar, Scielo, among others. By evaluating data from patients treated in the ophthalmology service of the National Pediatric Hospital Juan P. Garrahan, from 1987 to 2009. Thesis study published in 2015 by María del Pino Cidad Betegón, performed at the Children's Ophthalmology Service of the Hospital Universitario La Paz in Madrid, Spain. Collection of a retrospective study series based on records from 18 multicenter internships in various regions of the world. A total of 166 patients with bilateral retinoblastoma were analyzed in the ophthalmology service of the Graham pediatric hospital in the city of Buenos Aires, Argentina. It was observed that the visual acuity of the affected eyes was higher than 20/70 in 51.5% of the patients and lower in 48.5%. Study published by María del Pino Cidad Betegón, performed at the Children's Ophthalmology Service of the Hospital Universitario La Paz in Madrid, Spain between 1996 and 2013. As primary treatments, chemotherapy was performed in 59 out of 99 cases of unilateral retinoblastoma, 34 out of 99 cases in a primary way, while 24 cases required secondary enucleation, that is, it was performed after other treatments. Brachytherapy was used as consolidation treatment in 26 cases, which allowed 14 of these patients to avoid enucleation. The studies emphasize early diagnosis with a multidisciplinary approach and timely treatment of retinoblastoma by combining chemotherapy and consolidation techniques such as brachytherapy to improve the prognosis of cure and the quality of life of the patients.

Date: 2025
References: Add references at CitEc
Citations:

There are no downloads for this item, see the EconPapers FAQ for hints about obtaining it.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:dbk:procee:v:3:y:2025:i::p:1056294piii2025560:id:1056294piii2025560

Access Statistics for this article

More articles in SCT Proceedings in Interdisciplinary Insights and Innovations from AG Editor (Argentina)
Bibliographic data for series maintained by Javier Gonzalez-Argote ().