Calculating an intervention's (cost-)effectiveness for the real-world target population: The potential of combining strengths of both RCTs and observational data

Mattias Neyt, Irina Cleemput, Nancy Thiry and Chris De Laet

Health Policy, 2012, vol. 106, issue 2, 207-210

Abstract: Economic evaluations most often use results from randomised controlled trials (RCTs) to model effectiveness. Inconsiderate application of the absolute treatment effect from RCTs may result in unrealistic estimates of an intervention's benefit for the real-world target population. The baseline risk of events in this target population may differ significantly from the baseline risk in the RCT population.

Keywords: Methodology; Cost-benefit analysis; Effectiveness; Randomised controlled trial; Observational data (search for similar items in EconPapers)
Date: 2012
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:hepoli:v:106:y:2012:i:2:p:207-210

DOI: 10.1016/j.healthpol.2012.04.014

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