Genes, depressive symptoms, and chronic stressors: A nationally representative longitudinal study in the United States

Aniruddha Das

Social Science & Medicine, 2019, vol. 242, issue C

Abstract: •Polygenic risk for depression predicts late life exposure to chronic stressors.•Women's results suggest weak pleiotropy routed through depression.•These indirect effects are only on baseline stressor variations across individuals.•Men's patterns indicate direct pleiotropy on late life change in stressors.•Holistic life course models incorporating these biological effects are needed.

Date: 2019
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DOI: 10.1016/j.socscimed.2019.112586

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