Aminotransferase Activity Measurement on The Atellica® CH 930 and The Architect® ci4100

Soumia Nachate, Hind Zrikem, Fayrouz Debbagh, Saliha Chellak and Abderrahman Boukhira

European Journal of Biology and Biotechnology, 2023, vol. 4, issue 3, 41-45

Abstract: The Atellica® CH 930 is a new biochemistry analyzer recently introduced to the world market. This study aims to compare the Atellica® CH 930 analyzer to the Architect® ci4100 analyzer for measurement of serum aspartate (AST) and alanine (ALT) aminotransferase concentrations. A total of 112 sera were tested on the Architect® ci4100 and the Atellica® CH 930 analyzers for ALT and AST activities, and the results were compared using the paired Student's t-test, Pearson’s correlation analysis, Passing-Bablok regression analysis, and Bland–Altman plots. There was no significant difference between the means of the ALT and AST concentrations measured using the two instruments (p = 0.659 and p = 0.506, respectively). For ALT, the Passing-Bablok equation was Atellica=1.11 ×Architect -0.96, with a correlation coefficient (r) of 0.999. For AST, it was Atellica=1.08 ×Architect -0.50, with r = 0.998. According to Bland-Altman plots, the mean difference between both methods was 2.3 IU/L (4.3%) for ALT and 2.1 IU/L (5.8%) for AST, with 95.53% and 96.43% of points within the interval [0 ± 1.96 × SD], respectively. These findings demonstrated that the Atellica® CH 930 and Architect® ci4100 methods had an overall good agreement in aminotransferase measurement.

Keywords: Agreement; alanine aminotransferase; aspartate aminotransferase; method comparison (search for similar items in EconPapers)
Date: 2023
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://eu-opensci.org/index.php/ejbio/article/view/17472 Abstract page (text/html)
https://eu-opensci.org/index.php/ejbio/article/download/17472/4288 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:epw:ejbio0:v:4:y:2023:i:3:id:17472

DOI: 10.24018/ejbio.2023.4.4.472

Access Statistics for this article

More articles in European Journal of Biology and Biotechnology from European Open Science
Bibliographic data for series maintained by Support Team ().