Craniofacial and Ocular Anomalies in Paediatric Pituitary Dwarfism: A Systematic Review

Nikos Georgousis, Anastasia Mistea, Athanasia Grigoroudi, Evangelia Piperi and Charis Liapi
Additional contact information
Nikos Georgousis: National and Kapodistrian University of Athens, Greece
Anastasia Mistea: National and Kapodistrian University of Athens, Greece
Athanasia Grigoroudi: National and Kapodistrian University of Athens, Greece
Evangelia Piperi: National and Kapodistrian University of Athens, Greece
Charis Liapi: National and Kapodistrian University of Athens, Greece

European Journal of Dental and Oral Health, 2026, vol. 7, issue 2, 6-12

Abstract: This systematic review synthesizes contemporary research on the confluence of craniofacial and ocular anomalies in paediatric pituitary dwarfism, incorporating a robust qualitative risk-of-bias assessment. Following PRISMA 2021 guidelines, eligible articles (2021–2025) were retrieved from PubMed, Scopus, and other major databases. The ROBINS-I tool identified moderate to serious methodological challenges, chiefly around confounding and inconsistent outcome reporting, underscoring the complexity of synthesizing data across diverse study designs. Despite heterogeneity in diagnostic criteria and sample populations, a meta-analytic subset revealed a significant correlation between pituitary hormone deficiency and craniofacial dysmorphologies, alongside concomitant ocular pathologies. Early, multidisciplinary intervention—encompassing genetic counselling, endocrinologic management, and craniofacial assessment— emerged as critical for optimizing patient outcomes. Future research employing standardized protocols and larger cohorts will be pivotal in refining diagnostic precision and therapeutic strategies, ultimately enhancing quality of life for this unique paediatric population.

Keywords: Craniofacial anomalies; ocular disorders; pituitary dwarfism (search for similar items in EconPapers)
Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://eu-opensci.org/index.php/ejdent/article/view/13382 Abstract page (text/html)
https://eu-opensci.org/index.php/ejdent/article/download/13382/14019 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:epw:ejdent:v:7:y:2026:i:2:id:13382

DOI: 10.24018/ejdent.2026.7.2.13382

Access Statistics for this article

More articles in European Journal of Dental and Oral Health from European Open Science
Bibliographic data for series maintained by Support Team ().