Flutamide Induced Liver Injury in Female Patients

Nikola Malešević, Goran Bokan and Vlado Đajić
Additional contact information
Nikola Malešević: University Clinical Center of Republic of Srpska, Bosnia and Herzegovina
Goran Bokan: University Clinical Center of Republic of Srpska, Bosnia and Herzegovina
Vlado Đajić: University Clinical Center of Republic of Srpska, Bosnia and Herzegovina

European Journal of Medical and Health Sciences, 2020, vol. 2, issue 5

Abstract: Flutamide is the active substance of the drug and belongs to the group of drugs that have antiandrogenic effect. Flutamide prevents the action of male sex hormones, i.e. suppresses the action of testosterone and dihydrotestosterone. Primarily, the indications for the use of flutamide refer to males and the treatment of advanced prostate cancer. It is also used in the treatment of patients with testicles surgically removed, and in patients who have not responded to another type of therapy or do not tolerate other types of treatment. The efficacy of flutamide has also been proven in the treatment of acne, hirsutism and alopecia in men and women with polycystic ovaries. It is important to emphasize that flutamide can cause severe side effects, above all liver damage, so it is not justified to use it in the treatment of conditions other than prostate cancer. Numerous data on hepatotoxicity (retrospective, prospective studies, case reports, surveillance study) were available in literature, which ranged from asymptomatic to acute, fulminant hepatitis that ended in transplantation, i.e. fatal outcome. In our paper, a review of the literature with case reports of notably hepatotoxicity is presented along with a case from our clinical practice.

Keywords: Flutamide; Drug Induced Liver injury; Fulminant hepatitis; Liver transplant; Liver toxicity (search for similar items in EconPapers)
Date: 2020
References: Add references at CitEc
Citations:

Downloads: (external link)
https://eu-opensci.org/index.php/ejmed/article/view/40476 Abstract page (text/html)
https://eu-opensci.org/index.php/ejmed/article/download/40476/9040 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:epw:ejmed0:v:2:y:2020:i:5:id:40476

DOI: 10.24018/ejmed.2020.2.5.476

Access Statistics for this article

More articles in European Journal of Medical and Health Sciences from European Open Science
Bibliographic data for series maintained by Support ().