Surveillance of Viral Hemorrhagic Fever Viruses in Lassa Fever Suspects in Ondo State, Nigeria

Azuka Patrick Okwuraiwe, Oumar Faye, Fehintola Anthonia Ige, Ayorinde Babatunde James, Joseph Ojonugwa Shaibu, Martin Faye, Olufemi Samuel Amoo, Oumar NDiaye, Olumuyiwa Babalola Salu, Sunday Aremu Omilabu and Rosemary Ajuma Audu
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Azuka Patrick Okwuraiwe: Nigerian Institute of Medical Research, Nigeria
Oumar Faye: Institute Pasteur, Senegal
Fehintola Anthonia Ige: Nigerian Institute of Medical Research, Nigeria
Ayorinde Babatunde James: Nigerian Institute of Medical Research, Nigeria
Joseph Ojonugwa Shaibu: Nigerian Institute of Medical Research, Nigeria
Martin Faye: Institute Pasteur, Senegal
Olufemi Samuel Amoo: Nigerian Institute of Medical Research, Nigeria
Oumar NDiaye: Institute Pasteur, Senegal
Olumuyiwa Babalola Salu: University of Lagos, Nigeria
Sunday Aremu Omilabu: University of Lagos, Nigeria
Rosemary Ajuma Audu: University of Lagos, Nigeria

European Journal of Medical and Health Sciences, 2022, vol. 4, issue 3, 78-81

Abstract: Lassa Fever (LF) continues to be an endemic acute viral hemorrhagic fever (VHF) illness in Nigeria. Many suspected cases of LF infection have subsequently been confirmed negative and raises concerns as to what the diagnosis of such patients could be. Hence this study was to determine the causative agents of unconfirmed LF among initially suspected cases in South Western Nigeria. In this retrospective study, blood samples originally collected from 233 suspected cases of a LF outbreak response at Owo and Ose LGAs of Ondo State, were transported in triple level packaging and stored at -80°C. All samples were screened for LF IgM and IgG markers and LF PCR. Forty-five out of the stored plasma samples were randomly retrieved and analyzed for presence of IgM for seven other VHF viruses; Chikungunya (CHIK), West Nile (WN), Rift Valley fever (RVF), Yellow fever (YF), Dengue fever (DEN), Zika and Crimean-Congo hemorrhagic fever (CCHF). Out of 45 samples screened, 1 (2.2%) was positive for YF IgM antibody. The same sample was previously confirmed LF positive by PCR. This LF and YF co-infection was from a male, 23-year old individual. The presence of co-infections of LF and YF draw to limelight the need to be broad minded in exploring for the presence of other VHF viruses in outbreaks. Further studies are needed to decipher the diagnosis of LF suspected cases.

Keywords: Lassa; viral hemorrhagic fever; yellow fever virus (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:epw:ejmed0:v:4:y:2022:i:3:id:41245

DOI: 10.24018/ejmed.2022.4.3.1245

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