Term Pregnancy Woman with Human Immunodeficiency Virus Infection and Antiretroviral Therapy as Risk Factor of High Caspase-3 Expression in Placenta

Denni Prasetyo, I Wayan Artana Putra, Tjokorda G. A. Suwardewa, I Nyoman Hariyasa Sanjaya, Anom Suardika and I Gde Sastra Winata
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Denni Prasetyo: Sanglah General Hospital, Indonesia
I Wayan Artana Putra: Sanglah General Hospital, Indonesia
Tjokorda G. A. Suwardewa: Sanglah General Hospital, Indonesia
I Nyoman Hariyasa Sanjaya: Sanglah General Hospital, Indonesia
Anom Suardika: Sanglah General Hospital, Indonesia
I Gde Sastra Winata: Sanglah General Hospital, Indonesia

European Journal of Medical and Health Sciences, 2022, vol. 4, issue 3, 42-45

Abstract: Aim: To determine whether term pregnant women with human immunodeficiency virus infection who received antiretroviral therapy have a high Caspase-3 expression in the placenta. Methods: This cross-sectional analytical study was conducted at Sanglah General Hospital, Denpasar, and affiliated hospitals. Subjects were termed pregnant women with HIV (+) who received a minimum of six months of antiretroviral therapy as a risk group and pregnant women with HIV (-) as a non-risk group. Caspase-3 expression was assessed by immunohistochemical examination of placental tissue. The cut-off value for caspase-3 levels was determined by constructing a receiver operating characteristics (ROC) curve. The difference in proportion was assessed by the chi-square test, and the prevalence ratio (PR) was reported. The significance of this study was p

Keywords: Antiretroviral therapy; Caspase-3; human immunodeficiency virus; term pregnancy (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:epw:ejmed0:v:4:y:2022:i:3:id:41324

DOI: 10.24018/ejmed.2022.4.3.1324

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