Development and Validation of UV-VIS Spectrophotometric Method for Estimation of Methylprednisolone from Dissolution Media

Mhetre M. N. and Kalshetti M. S.

International Journal of Scientific Research in Science and Technology, 2024, vol. 11, issue 3, 437-441

Abstract: A simple, accurate UV-Spectrophotometric method has been developed using a dissolution media, 0.1% Tween 20 as a solvent to determine the methylprednisolone. At a predetermined λmax of 245 nm, method was proved linear in the range of 5-40 μg/ml with good correlation coefficient (R2=0.998) and excellent recovery (between 98 and 101%). This method was successfully applied to the determination of methylprednisolone from dissolution media, 0.1% Tween 20 aqueous solution. This method can be employed for the dissolution study of methylprednisolone in injectable suspension.

Keywords: Methylprednisolone; UV-Spectrophotometer; Dissolution; Injectable Suspension (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v11:y2024:i3:id:203

DOI: 10.32628/IJSRST24113116

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