Evaluation of the Antimicrobial Activities of Some Metal (Ii) Pyrimethamine Complexes

Tasiu Dahiru, Bilya Abdu and Dauda Hassan Lamuntani

International Journal of Scientific Research in Science and Technology, 2024, vol. 11, issue 4, 61-68

Abstract: The research work focused on the synthesis and antimicrobial studies of complexes of Manganese (II), Cobalt (II) and Nickel (II) with 5-(-4-Chlorophenyl)-6ethylpyrimidinediamiane (pyrimethamine) which serve as ligand. The complexes were prepared by direct combination of aqueous solution of the metal ions with the solution of pyrimethamine drug in methanol. The metal complexes were then characterized by conductance measurement, determination of decomposition temperature and infrared spectral analysis. The spectral analysis shows the ligand as bidental and coordinates to the metals through the nitrogen atom of the respective amine groups. Elemental analysis shows that all the complexes have octahedral configuration [ML2CL2], Where L = Ligand and M = metal. Molar conductance measurement and decomposition temperature analysis indicate that all the complexes are stable, non-electrolytes chelates. Antimicrobial evaluation of the complexes shows varied degree of inhibitory effect against some bacterial and fungal isolates; staphylococcus aureus, escheria coli, salmonella typhi and mucor spp and Rhizopus spp. However the antimicrobial activity of Mn(II) complex was found to be greater than cobalt (II) and Nickel (II) Complexes.

Keywords: Manganese; Cobalt; Nickel; Staphylococcus Aureus; Escheria Coli; Salmonella Typhi; Mucor Spp; Rhizopus Spp (search for similar items in EconPapers)
Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
https://ijsrst.com/home/article/view/IJSRST24114106 Abstract page (text/html)
https://ijsrst.com/home/article/download/IJSRST24114106/IJSRST24114106 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v11:y2024:i4:id:258

DOI: 10.32628/IJSRST24114106

Access Statistics for this article

More articles in International Journal of Scientific Research in Science and Technology from Technoscience Academy
Bibliographic data for series maintained by Pankaj Sharma ().