Synthesis of Tetrazole Tethered Tetrahydrobenzo [B] Thiophene-3-Carbonitrile by Isocyanide-Based Condensation

Priyal Sukhwal, Akash Kalundha, Repale anil Vithal, Chundawat N.s, Pathan Sultan Ismail and Girdhar Pal Singh

International Journal of Scientific Research in Science and Technology, 2025, vol. 12, issue 2, 234-243

Abstract: Tetrazole-tethered tetrahydrobenzo[b]thiophene-3-carbonitrile derivatives have gained significant attention due to their diverse biological and pharmaceutical applications. In this study, we present an efficient synthesis of tetrazoles using an isocyanide-based multicomponent condensation strategy. The reaction involves a nitrile as precursor, isocyanide, aldehyde, and a sulfur source under optimized catalytic conditions, leading to the formation of highly functionalized frameworks. Furthermore, the cyclization of the nitrile with sodium azide facilitates the introduction of the tetrazole moiety, enhancing the molecular complexity. The developed methodology provides a facile, high-yielding, and sustainable approach to constructing novel heterocyclic scaffolds with potential medicinal relevance.

Keywords: Synthesis Of Tetrazole; Tetrahydrobenzo B Thiophene-3-Carbonitrile; Tethered Tetrahydrobenzo; Thiophene-3-Carbonitrile By Isocyanide-Based; Condensation (search for similar items in EconPapers)
Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://ijsrst.com/home/article/view/IJSRST25122212 Abstract page (text/html)
https://ijsrst.com/home/article/download/IJSRST25122212/IJSRST25122212 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v12:y2025:i2:id:649

DOI: 10.32628/IJSRST25122212

Access Statistics for this article

More articles in International Journal of Scientific Research in Science and Technology from Technoscience Academy
Bibliographic data for series maintained by Pankaj Sharma ().