Development and Validation of a Simultaneous HPLC Method for Quantification of Atenolol and Amlodipine Besylate in Tablet Form

Harshvardhan Tanpure and Dattatray Jirekar

International Journal of Scientific Research in Science and Technology, 2026, vol. 13, issue 1, 399-406

Abstract: A Reverse phase method has been developed for the quantitative estimation of Atenolol and Amlodipine Besylate in Tablets. The Quantification was carried out using RP stainless steel column ODS C18 250 x 4.6 x 5 μ L1 packing in Isocratic mode with mobile phase containing 0.03 M potassium buffer: Acetonitrile in the ratio of 50:50 Adjust pH3.5 with ortho-phosphoric acid. Degas this solution before use. Flow rate 1.0 ml/minute and the detection wavelength was set at 237 nm and the linearity was found to be in the range of 16-22 ug/ml for Atenolol and 8 to 12 ug/ml for Amlodipine Besylate. The proposed method was found to be simple, precise, accurate, reproducible for the Estimation of Atenolol and Amlodipine Besylate.

Keywords: Atenolol and Amlodipine Besylate Method development Validation; High performance liquid chromatography; quantification (search for similar items in EconPapers)
Date: 2026
References: Add references at CitEc
Citations:

Downloads: (external link)
https://ijsrst.com/home/article/view/IJSRST2613158 Abstract page (text/html)
https://ijsrst.com/home/article/download/IJSRST2613158/IJSRST2613158 Full text (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v13:y2026:i1:id:1410

DOI: 10.32628/IJSRST2613158

Access Statistics for this article

More articles in International Journal of Scientific Research in Science and Technology from Technoscience Academy
Bibliographic data for series maintained by Pankaj Sharma ().