Gold Electrode Modified with Vanadium Dioxide and Graphene Oxide for Non-Enzymatic Electrochemical Detection of Glucose

E. T. S. Neves, R. G. Cunha Filho, E. M. Guerra and D. T. Cestarolli

International Journal of Scientific Research in Science and Technology, 2026, vol. 13, issue 2, 876-887

Abstract: This work presents the development of a non-enzymatic glucose sensor based on a gold electrode modified with a composite of vanadium dioxide (VO2) and graphene oxide (GO). The VO2 was synthesized via a facile hydrothermal method and combined with GO to form a thin film on the Au electrode surface. The electrochemical behavior of the Au/VO2-GO electrode was thoroughly investigated. The modified electrode exhibited a pH sensitivity of 58.0 ± 0.02 mV/pH, closely approximating the theoretical Nernstian response. The electrocatalytic activity towards glucose oxidation was assessed using cyclic voltammetry and square-wave voltammetry in synthetic urine. The anodic peak current increased linearly with glucose concentration in the range of 4.0 to 5.4 mmol.L⁻¹. The sensor demonstrated a detection limit of 0.65 mmol L⁻¹ and a quantification limit of 2.15 mmol.L⁻¹. The electrochemical process was identified as diffusion-controlled. Despite a relatively low electroactive surface area (roughness factor = 1.3 × 10-3), the Au/VO2-GO electrode showed promising sensitivity and stability for non-enzymatic glucose detection, suggesting potential for application in clinical analysis.

Keywords: glucose sensor; non-enzymatic detection; vanadium dioxide; graphene oxide; modified electrode (search for similar items in EconPapers)
Date: 2026
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Persistent link: https://EconPapers.repec.org/RePEc:etm:ijsrst:v13:y2026:i2:id:1536

DOI: 10.32628/IJSRST2613114

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