Exposure to Endocrine Disrupters and Nuclear Receptor Gene Expression in Infertile and Fertile Women from Different Italian Areas

Cinzia La Rocca, Sabrina Tait, Cristiana Guerranti, Luca Busani, Francesca Ciardo, Bruno Bergamasco, Laura Stecca, Guido Perra, Francesca Romana Mancini, Roberto Marci, Giulia Bordi, Donatella Caserta, Silvano Focardi, Massimo Moscarini and Alberto Mantovani
Additional contact information
Cinzia La Rocca: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
Sabrina Tait: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
Cristiana Guerranti: Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy
Luca Busani: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
Francesca Ciardo: Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy
Bruno Bergamasco: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
Laura Stecca: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
Guido Perra: Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy
Francesca Romana Mancini: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy
Roberto Marci: Department of Biomedical Sciences and Advanced Therapies, Section of Obstetrics and Gynaecology, University of Ferrara, Ferrara 44121, Italy
Giulia Bordi: Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy
Donatella Caserta: Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy
Silvano Focardi: Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy
Massimo Moscarini: Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy
Alberto Mantovani: Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy

IJERPH, 2014, vol. 11, issue 10, 1-19

Abstract: Within the PREVIENI project, infertile and fertile women were enrolled from metropolitan, urban and rural Italian areas. Blood/serum levels of several endocrine disrupters (EDs) (perfluorooctane sulfonate, PFOS; perfluorooctanoic acid, PFOA; di-2-ethylhexyl-phthalate, DEHP; mono-(2-ethylhexyl)-phthalate, MEHP; bisphenol A, BPA) were evaluated concurrently with nuclear receptors (NRs) gene expression levels (ERa, ERb, AR, AhR, PPARg, PXR) in peripheral blood mononuclear cells (PBMCs). Infertile women from the metropolitan area displayed significantly higher levels of: BPA compared to fertile women (14.9 vs. 0.5 ng/mL serum); BPA and MEHP compared to infertile women from urban and rural areas; enhanced expression levels of NRs, except PPARg. Infertile women from urban and rural areas had PFOA levels significantly higher than those from metropolitan areas. Our study indicates the relevance of the living environment when investigating the exposure to EDs and the modulation of the NR panel in PBMC as a suitable biomarker of the effect, to assess the EDs impact on reproductive health.

Keywords: human exposure; women infertility; PFOS; PFOA; BPA; DEHP; MEHP; biomarkers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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