Maize Purple Plant Pigment Protects Against Fluoride-Induced Oxidative Damage of Liver and Kidney in Rats

Zhuo Zhang, Bo Zhou, Hiaohong Wang, Fei Wang, Yingli Song, Shengnan Liu and Shuhua Xi
Additional contact information
Zhuo Zhang: Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, China
Bo Zhou: Department of Nutrition and Food Hygiene, Shenyang Medical College, No146 Huanghe North Street, Shenyang 110034, China
Hiaohong Wang: Department of Nutrition and Food Hygiene, Shenyang Medical College, No146 Huanghe North Street, Shenyang 110034, China
Fei Wang: Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, China
Yingli Song: Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, China
Shengnan Liu: Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, China
Shuhua Xi: Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 92 Bei Er Road, Heping District, Shenyang 110001, China

IJERPH, 2014, vol. 11, issue 1, 1-14

Abstract: Anthocyanins are polyphenols and well known for their biological antioxidative benefits. Maize purple plant pigment (MPPP) extracted and separated from maize purple plant is rich in anthocyanins. In the present study, MPPP was used to alleviate the adverse effects generated by fluoride on liver and kidney in rats. The results showed that the ultrastructure of the liver and kidney in fluoride treated rats displayed shrinkage of nuclear and cell volume, swollen mitochondria and endoplasmic reticulum and vacuols formation in the liver and kidney cells. MPPP significantly attenuated these fluoride-induced pathological changes. The MDA levels in serum and liver tissue of fluoride alone treated group were significantly higher than those of the control group ( p < 0.05). The presence of 5 g/kg MPPP in the diet reduced the elevation of MDA levels in blood and liver, and increased the SOD and GSH-Px activities in kidney and GSH level in liver and kidney compared with the fluoride alone treated group ( p < 0.05). In addition, MPPP alleviated the decrease of Bcl-2 protein expression and the increase of Bax protein expression induced by fluoride. This study demonstrated the protective role of MPPP against fluoride-induced oxidative stress in liver and kidney of rats.

Keywords: fluoride; oxidative stress; anthocyanins; maize purple plant pigment; rats (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/11/1/1020/pdf (application/pdf)
https://www.mdpi.com/1660-4601/11/1/1020/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:11:y:2014:i:1:p:1020-1033:d:32091

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().