Associations of Serum Retinol, ?-Tocopherol, and ?-Tocopherol with Biomarkers among Healthy Japanese Men

Yu Zou, Da-Hong Wang, Noriko Sakano, Yoshie Sato, Suketaka Iwanaga, Kazuhisa Taketa, Masayuki Kubo, Kei Takemoto, Chie Masatomi, Kiyomi Inoue and Keiki Ogino
Additional contact information
Yu Zou: Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Da-Hong Wang: Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Noriko Sakano: Department of Gerontology Research, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Yoshie Sato: Graduate School of Health Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Suketaka Iwanaga: Department of Public Health, Faculty of Medicine, Kyoto University, Yoshida-Konoye-cho Sakyo-ku, Kyoto 606-8501, Japan
Kazuhisa Taketa: Geriatric Health Service Facility, Niwanosato Home, Mihara, Hiroshima 729-1321, Japan
Masayuki Kubo: Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Kei Takemoto: Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Chie Masatomi: Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
Kiyomi Inoue: Public Health Care Nursing, Department of Nursing, Faculty of Health Sciences, Kobe Tokiwa University, 2-6-2 Otani-cho, Kobe 653-0838, Japan
Keiki Ogino: Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan

IJERPH, 2014, vol. 11, issue 2, 1-14

Abstract: Retinol, ?-tocopherol, and ?-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23–67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (? = 0.344, p = 0.001) and ?-tocopherol levels (? = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (? = ?0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (? = ?0.262, p = 0.021), ?-tocopherol (? = ?0.236, p = 0.035), and ?-tocopherol levels (? = ?0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum ?-tocopherol (? = ?0.286, p = 0.008) and ?-tocopherol (? = ?0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (? = ?0.211, p = 0.032) and ?-tocopherol levels (? = ?0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.

Keywords: serum retinol; serum ?-tocopherol; serum ?-tocopherol; HOMA-R; serum ferritin; smoking; alcohol consumption (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2014
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/11/2/1647/pdf (application/pdf)
https://www.mdpi.com/1660-4601/11/2/1647/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:11:y:2014:i:2:p:1647-1660:d:32676

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().